NL – Enclomiphene

Enclomiphene is a selective estrogen receptor modulator (SERM) that has gained attention for its potential applications in the field of reproductive medicine. This compound is an isomer of clomiphene, a well-known drug used to treat infertility in women by inducing ovulation. Enclomiphene specifically refers to the trans isomer of clomiphene and is believed to exhibit greater specificity for estrogen receptors.

One of the primary mechanisms of action of enclomiphene is its ability to modulate estrogen receptor activity. It acts as an estrogen receptor antagonist, meaning it competes with endogenous estrogens for binding to estrogen receptors. By blocking the effects of estrogen, enclomiphene exerts its influence on the hypothalamus and pituitary glands, ultimately leading to increased production of gonadotropins such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

The enhanced secretion of LH and FSH can be particularly beneficial in the context of male reproductive health. Enclomiphene has been investigated as a potential treatment for male hypogonadism, a condition characterized by low testosterone levels. By stimulating the production of LH, enclomiphene promotes the natural production of testosterone in the testes, offering a non-invasive alternative to traditional testosterone replacement therapies.

Furthermore, enclomiphene’s impact on testosterone levels may be of interest in the context of sports medicine and performance enhancement. Some athletes have explored the use of SERMs to boost endogenous testosterone production, with the aim of improving muscle mass, strength, and overall athletic performance. However, the use of enclomiphene or similar compounds for such purposes raises ethical and health-related concerns, as well as potential violations of anti-doping regulations.

While enclomiphene shows promise in certain areas, it is essential to acknowledge the potential risks and side effects associated with its use. Like any medication, enclomiphene may cause adverse reactions, including but not limited to hot flashes, mood swings, and visual disturbances. Moreover, the long-term safety and efficacy of enclomiphene in various patient populations are still areas of active research.

In conclusion, enclomiphene represents a fascinating avenue of exploration in the realm of reproductive medicine and endocrinology. Its ability to modulate estrogen receptor activity and stimulate gonadotropin release has implications for both male fertility treatment and potential applications in sports medicine. However, ongoing research is crucial to better understand the full spectrum of its effects, establish appropriate dosages, and ensure the safety of its use in different clinical scenarios.

How to use Enclomiphene?

In order to be 100% of what your levels are, it’s highly recommended to get your bloodwork done to see exactly how an Enclomiphene PCT is affecting you.

Additionally, Enclomiphene is relatively new to the bodybuilding scene and anecdotal evidence is scarce, so dosage is hard to determine. Let’s use this study for reference (10).

Based of this, you could follow the following protocol:

• Extra-heavy dose period – Take 50mg of the medication for 14 days, every day.
• After heavy dose period – Take 25mg of the medication for 14 days, every day.
• Average dose – Take 12.5mg of the medication for 14 days, every day.